Publications
2025
Rousseau, M., Geraldes, P. (2025). Phophatases and kidney diseases. Current Opinion in Physiology. Accepted
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Nadeau N., Ouellet M., Béland R., Mercier C., Robillard R., Lizotte F., Despatis M-A., Bentzinger CF., Geraldes P. (2025). Endothelial SHP-1 regulates diabetes-induced abnormal collateral vessel formation and endothelial cell senescence. Journal of Molecular and Cellular Cardiology; 202:50-63.
Tremblay R., Marcotte-Chénard A., Deslauriers L., Boulay P., Boisvert F-M., Geraldes P., Gayda M., Christou D., Little J., Mampuya W., Riesco E. (2025). Acute Effect of High-Intensity Interval Exercise on Blood Pressure in Females Living with Type 2 Diabetes and Hypertension. Med Sci Sports Exerc; In Press doi: 10.1249/MSS.0000000000003639
2024
Sauge E., White Z., Lizotte F., Yuen C., Atmuri P., Ciufolini MA., Geraldes, P., Bernatchez PN. (2024). Losartan and metabolite EXP3179 activate endothelial function without lowering blood pressure in AT2 receptor KO mice. Eur J Pharmacol; 977:176663.
Marcotte-Chénard A., Tremblay R., Deslauriers L., Geraldes P., Gayda M., Christou D., Mampuya W., Little JP., Riesco E. (2024). Comparison of 10 × 1-minute high-intensity interval training (HIIT) versus 4 × 4-minute HIIT on glucose control and variability in females with type 2 diabetes. Appl Physiol Nutr Metab; 49(4):487-500.
2023
Lizotte F., Rousseau M., Denhez B., Levesque D., Guay A., Liu H., Moreau J., Higgins S., Sabbagh R., Susztak K., Boisvert F-M., Cote A-M., Geraldes P. (2023). Deletion of SHP-1 restores SUMOylation of podocin and reverses the progression of diabetic kidney disease. Kidney International; 104(6): 1228.
Robillard R., Trân K., Lachance M-S., Brazeau T., Boisvert E., Lizotte F., Auger-Messier M., Boudreault P-L., Marsault E., Geraldes P. (2023). Apelin prevents diabetes-induced poor collateral vessel formation and blood flow reperfusion in ischemic limb. Frontiers Cardiovascular Medicine; 10(1191891): 1-17.
Barrera-Chimal J., Henley N., Grant M., Cenatus S., Geraldes P., Pichette V., Gerarduzzi C. (2023). Tungsten toxicity on kidney tubular epithelial cells induces renal inflammation and M1-macrophage polarization. Cell Biology and Toxicology; 1: 1-23.
Marcotte-Chénard A., Tremblay R., Deslauriers, L; Geraldes, P., Gayda M., Christou D., Mampuya W., Little J., Riesco E. (2023). Comparison of 10 × 1-minute high-intensity intervaltraining (HIIT) versus 4 × 4- minute HIIT on glucose control and variability infemales with type 2 diabetes. Applied Physiology, Nutrition, and Metabolism; 1: 1-20.
2022
Lizotte F., Robillard S., Lavoie N., Rousseau M., Denhez B., Moreau J., Higgins S., Sabbagh R., Côté A-M., Geraldes P. (2022) Enhanced SHP-1 expression in podocyturia is associated with kidney dysfunction in patients with diabetes. Kidney 360; 3(10): 1710-19.
Rousseau M., Denhez B., Crysta S., Guay A., Lizotte F., Côté A-M., Burger D., Geraldes P. (2022) Reduction of DUSP4 contributes to podocytes oxidative stress, insulin resistance and diabetic nephropathy. Biochemical and Biophysical Research Communications; 624: 127-33.
Hamelin Morrissette J.*, Tremblay D.*, Marcotte-Chénard A., Lizotte F., Brunet M.A., Laurent B. Riesco E., Geraldes P. (2022). Transcriptomic Modulation in Response to High-Intensity Interval Training in Monocytes of Older Women with Type 2 Diabetes. European Journal of Applied Physiology; 122(4): 1085-1095 *Equal contribution
2021
Mercier C., Brazeau T., Lamoureux J., Boisvert E., Robillard S., Breton V., Paré M., Guay A., Lizotte F., Despatis M-A., Geraldes P. (2021) Diabetes impaired ischemia-induced PDGF signaling actions and vessel formation through the activation of Scr homology 2-containing phosphatase-1. Arterioscler Thromb Vasc Biol; 41(9): 2469-2482.
Perazza L.R., Mitchell P., Lizotte F., Jensen B., St-Pierre P., Trottier J., Barbier O., Mathieu P., Geraldes P., Marette A. (2021) Fish oil replacement prevents, while DHA-derived protectin DX mitigates end-stage renal-disease in atherosclerotic diabetic mice. FASEB J.; 35(5):e21559. doi: 10.1096/fj.202100073R.
Mercier C., Rousseau M., Geraldes P. (2021) Growth factor deregulation and emerging role of phosphatases in diabetic peripheral artery disease. Frontiers in Cardiovascular Medicine; 7(619612): 1-13.
Croteau L., Mercier C., Fafard-Couture E., Nadeau A., Robillard S., Breton V., Guay A., Lizotte F., Despatis M-A., Geraldes P. (2021) Endothelial deletion of PKCδ prevents VEGF inhibition and restores blood flow reperfusion in diabetic ischaemic limb. Diabetes and Vascular Disease Research; 18(2): 1479164121999033.
2020
Denhez B., Rousseau M., Dancosst D-A., Guay A., Dumas M-E., Lizotte F., Côté A-M., Geraldes P. (2020) Saturated fatty acids induce insulin resistance in podocytes through inhibition of IRS1 via both activation of IKKβ and mTORC1. Sci Rep; 10(1):21628. doi: 10.1038/s41598-020-78376-1.
Robillard S., Mercier C., Breton V., Paquin-Veillette J., Lizotte F., Geraldes P. (2020) Ablation of AT2 receptor prevents eNOS glutathionylation and nitration in ischemic abductor muscle of diabetic mice. Diabetes Vascular Disease Research; 17(1): 1479164119883978.
2019
Lacroix M., Lizotte F., Hivert M-F., Geraldes P.*, Perron P.* (2019) Calcifediol stimulation decreases interleukin-6 secretion by cultured human trophoblasts from GDM pregnancies. Journal of the Endocrine Society; 3(11): 2165-2178. *contributed equally as senior authors.
Quiroga DT, Miquet JG, Gonzalez L, Sotelo AI, Muñoz MC, Geraldes PM, Giani JF, Dominici FP. (2019) Mice lacking angiotensin type 2 receptor exhibit a sex-specific attenuation of insulin sensitivity. Mol Cell Endocrinol; 498:110587.
Denhez B., Rousseau M., Dancosst D-A., Lizotte F., Guay A., Auger-Messier M., Côté A-M., Geraldes P. (2019) Diabetes-induced DUSP4 reduction promotes podocyte dysfunction and progression of diabetic nephropathy. Diabetes; 68(5):1026-1039.
2018
Barrière D.A., Noll C., Roussy G., Lizotte F., Kessai A., Kirby K., Belleville K., Beaudet N., Longpré J.M., Carpentier A.C., Geraldes P., Sarret P. (2018) Combination of high-fat/high-fructose diet and low-dose streptozotocin to model long-term type-2 diabetes complications. Sci Rep; 8(1):424.
Geraldes P. (2018) Protein Phosphatase and podocyte function. Current Opinion in Nephrology and Hypetension; 27(1):49-55.
2017
Paquin-Veillette J., Lizotte F., Robillard S., Béland R., Breton M-A., Guay A., Despatie M-A., Geraldes P. (2017) Deletion of AT2 receptor prevents SHP-1 causing VEGF inhibition and improves blood flow reperfusion in diabetic ischemic hindlimb. Arterioscler Thromb Vasc Biol; 37(12): 2291-2300.
Denhez, B., Geraldes P. (2017) Regulation of nephrin phosphorylation in diabetes and chronic kidney injury. Adv Exp Med Biol; 966:149-161.
2016
Lizotte F., Denhez B., Guay A., Gévry N., Côté A-M., Geraldes P. (2016) Persistent insulin resistance in podocytes caused by epigenetic changes of SHP-1 in diabetes. Diabetes; 65(12):3705-3717. 2015
2015
Durpès M-C., Morin C., Paquin-Veillette J., Béland R., Paré M., Guimond M-O., Rekhter M., King G.L., Geraldes P. (2015) PKC beta activation inhibits interleukin-18 binding protein causing endothelial dysfunction and accelerated diabetic atherosclerosis. Cardiovasc Research; 106(2): 303-13.
Denhez D., Lizotte F., Guimond M-O., Jones N., Takano T., Geraldes P. (2015) Increased SHP-1 expression by high glucose levels reduced nephrin phosphorylation in podocytes. J Biol Chem; 290(1): 350-8.
2013
Lizotte F., Pare M., Denhez B., Leigtes M., Guay A., Geraldes P. (2013) PKC Delta Impaired expression of angiogenic Factor Regulation and vessel formation in diabetic ischemic limb. Diabetes; 62(8): 2948-57.
Drapeau N., Lizotte F., Denhez B., Kennedy C., Guay A., Geraldes P. (2013) Activation of SHP-1 Expression by Hyperglycemia Prevents Insulin Actions in Podocytes. AJP – Endocrinology & Metabolism; 304(11): E1188-98
2012
Mima A., Hiraoka-Yamomoto J., Li Q., Kitada M., Li C., Geraldes P., Matsumoto M., Mizutani K., Park K., Cahill C., Nishikawa S.I., Rask-Madsen C., King G.L. (2012) Protective Effects of GLP-1 on glomerular endothelium and its inhibition by PKC-beta activation in diabetes. Diabetes; 61(11): 2967-79
Mima A., Kitada M., Geraldes P., Li Q., Matsumoto M., Mizutani K., Qi Q., Li C., Leitges M., Rask-Madsen C., King G.L. (2012) Glomerular VEGF resistance induced by PKCδ/SHP-1 activation and contribution to diabetic nephropathy. Faseb J; 36(7): 2963-74.
2011
Mima A., Ohshiro Y., Kitada M., Matsumoto M., Geraldes P., Li C., Li Q., White G.S., Cahill C., Rask-Madsen C., King G.L. (2011) Glomerular-specific protein kinase C--induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity. Kidney Int; 79(8): 883-96.
2010
Rask-Madsen C., Li Q., Abramov R., Wu I., Chen K., Freund B., Yamamoto-Hiraoka J., Goldenbogen J., Sotiropoulos K.B., Clermont A., Geraldes P., Dall'Osso C., Wagers A.J., Huang P.L., Rekhter M., Scalia R., Kahn C.R., King G.L. (2010) Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice. Cell Metabolism; 11(5): 379-89.
Geraldes P., King G.L. (2010) Activation of Protein Kinase C Isoforms and Its Impact on Diabetic Complications. Circulation Research; 106(8): 1319-31.
2009
Geraldes P., Hiraoka-Yamamoto J., Matsumoto M., Clermont A., Leigtes M., Marette A., Aiello L.P., Kern T.S., King G.L. (2009) Activation of PKC delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy. Nature Medicine; 15(11):1298-306.
Kondo T., El Khattabi I., Nishimura W., Laybutt D.R., Geraldes P., Shah S., King G., Bonner-Weir S., Weir G., Sharma A. (2009) P38 MAPK is a major regulator of MafA protein stability under oxidative stress. Mol Endocrinol; 23(8):1281-90.
2008
Geraldes P., Yagi K., Ohshiro Y., He Z., Maeno Y., Yamamoto-Hiraoka J., Rask-Madsen C., Chung S.W., Perrella M.A., King G.L. (2008) Selective Regulation of Heme Oxygenase-1 Expression and Function by Insulin Through IRS1/Phosphoinositide-3 Kinase/Akt-2 Pathway. Journal of Biological Chemistry; 283(49):34327-36.
Geraldes P., Geoffroy P., Cloutier I. Sirois M.G., Tanguay J-F. (2008) Local Delivery of 17-beta-Estradiol Modulates Collagen Content in Porcine Coronary Arteries After PTCA and Stent Implantation. J Vasc Res; 45(6):503-511.
2007
Geraldes P., Gosselin H., Tanguay J-F., Clement R., Calderone A. (2007) Tamoxifen Treatment of Myocardial Infarcted Female Rats Exacerbates Scar Formation. Pflugers Arch - Eur J Physiol; 454:385-393.
Geraldes P., Yamagata M., Rook S.L., Sassa Y., Ma R.C., Clermont A., Gao B., Aiello L.P., Feener E.P., King G.L. (2007) Glypican 4, a Membrane Binding Protein for Bactericidal/Permeability-Increasing Protein Signaling Pathways in Retinal Pigment Epithelial Cells. Invest Ophtalmol Vis Sci; 48:5750-5755.
2006
Geraldes P., Gagnon S., Hadjadj S., Merhi Y., Sirois M.G., Cloutier I., Tanguay J-F. (2006) Reduction of CD40 and CD40L Receptor Expression on Endothelial Cells by Estrogen: Role of Estrogen Receptor Alpha. Cardiovasc Res; 71:566-573
Yamagata M., Rook S.L., Sassa Y., Ma R.C., Geraldes P., Goddard L., Clermont A., Gao B., Salti H., Gundel R., White M., Feener E.P., Aiello L.P., King G.L. (2006) Bactericidal/Permeability-Increasing Protein’s Signaling Pathways and its Retinal Trophic and Anti-angiogenic Effects. FASEB J; 20:2058-2067.
2004
Gagnon C., Legault F., Geraldes P., Tanguay J-F., Lambert C. (2004) Diverse Effects of Ace Inhibitors and Angiotensin II Receptor Antagonists on Prevention of Cardiac Hypertrophy and Collagen Distribution in Spontaneously Hypertensive Rats. Int J Cardiol; 97:373-381
2003
Geraldes P., Sirois M.G., Tanguay J-F. (2003) Specific Contribution of Estrogen Receptors on Mitogen-Activated Protein Kinase Pathways and Vascular Cell Activation. Circ Res; 93:399-405.
2002
Geraldes P., Sirois M.G., Bernatchez P.N., Tanguay J-F. (2002) Estrogen Regulation of Endothelial and Smooth Muscle Cell Migration and Proliferation: Role of p38 and p42/44 Mitogen-Activated Protein Kinases. Arterioscler Thromb Vasc Biol; 22:1585-1590.