Diabetes macrovasculopathy is associated with structural and functional changes in large vessels that lead to blood flow obstruction, hypertension, myocardial infarction (MI) and possibly death. Atherosclerosis, characterized by endothelial dysfunction, cytokine expression, monocyte infiltration, SMC proliferation, impaired fibrinolysis combined with increased thrombosis, and chronic inflammation causes ischemic heart diseases, MI, stroke, and peripheral arterial diseases. Hyperglycemia is believed to participate in atherosclerotic plaque formation. My laboratory is interested in understanding the mechanisms of glucose and lipid metabolism induced monocyte activation and endothelial cell dysfunction which are responsible for the formation of the atherosclerotic plaque.